Efficacy of Budeprion XL vs. Wellbutrin XL in Depression sign now

February 17, 2008

Mike Leavitt, Secretary
Department of Health and Human Services
200 Independence Avenue, SW
Washington, DC 20201

Dear Secretary Leavitt,

We, the undersigned, request that the efficacy of the generic form of Wellbutrin XL (bupropion), known as Budeprion XL, be investigated. Many patients have become depressed after switching from the brand name version of bupropion to the generic form. In general, unless a doctor specifically requests a brand name only, pharmacies will automatically fill prescriptions with generic drugs. Additionally, insurance companies will often only pay for brand name medications when a generic is not available. Utilizing a potentially ineffective generic medication for the treatment of depression puts patients' health and safety at risk. Patients and physicians must be warned of the possibility of a worsening of symptoms while taking Budeprion XL. We urge you to consider the consequences of poorly controlled depression, and ask that you mandate independent testing of Budeprion XL to accurately determine its efficacy in depression.

The following links suggest the nature and extent of the problem:

NPR Recording

The People's Pharmacy Reports of Generic Drug Problems

Results of Consumer Lab Study Comparing Wellbutrin XL and Budeprion XL

MSNBC Health Article

Interview with CNN's Dr. Sanjay Gupta

The following link discusses the maker of brand name Wellbutrin XL's attempts to prevent sales of the generic drug by starting a petition "intended to protect the public against the potentially harmful effects of generic versions of Wellbutrin XL that may not be a bioequivalent to Biovail's branded product, or may be misleadingly labeled."


The following FDA site can be used to report adverse reactions to the generic form of Wellbutrin XL:



Conduct independent studies on the efficacy of Budeprion XL for depressive symptoms.

Require warning labels on dispensed prescriptions of Budeprion XL to indicate that Budeprion XL may not work as well for depression as the brand name Wellbutrin XL, and warn patients and physicians to monitor for a worsening of condition while on Budeprion XL.

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Latest Signatures

  • 08 June 2015100. Michele D
    Because Wellbutrin is a "step therapy" medication with my new HMO, I expect I will have to jump through hoops to get authorization for brand instead of generic. Since our employer switched HMOs I've had to switch back to generic budeprion (Teva). I'm now
  • 24 May 201599. Maria M
    I support this petition
  • 21 May 201598. Dawn T
    Generic drugs, in general, should be held to the same standards as brand name drugs. I find it deeply disconcerting and troublesome that people who are taking this specific generic drug, as many do with generic drugs--in an attempt to save money or as adv
  • 14 May 201597. Rob P
    I support this petition
  • 09 April 201596. Craig H
    I support this petition
  • 02 April 201595. Jon G
    I support this petition
  • 13 February 201594. Diane R
    I support this petition
  • 31 December 201493. Timothy D
    I support this petition
  • 03 October 201492. Steven P
    I support this petition
  • 03 October 201491. Carol L
    Medicare switched me to Bravo on the 1st of the year and they won't pay for 'name brand' meds. I've been taking Wellbutrin xl as part of my Bipolar 'cocktail' and and have been able to stay med-compliant for 10 years now. (I was first diagnosed in 1980) O
  • 30 August 201490. Arthur A
    I support this petition
  • 09 August 201489. Jennifer B
    В Address В Phone Number В
  • 06 July 201488. Joy O
    Has worsened my depression!
  • 24 June 201487. Alexis L
    I support this petition
  • 21 June 201486. Yoko K
    I support this petition
  • 20 June 201485. Brad W
    I support this petition
  • 14 May 201484. Shannon Ms
    I support this petition
  • 16 April 201483. Mallory Powell
    Please look into it! They are NOT the same.
  • 23 March 201482. Cynthia G
    I support this petition
  • 15 February 201481. Carrie L
    I support this petition
  • 09 February 201480. Cecile G
    iI is imperative that the FDA check generics. Budeprion is a nightmare! I am better off taking nothing, but need the results of Wellbutrion XL to function.
  • 08 January 201479. Joyce Z
    I support this petition
  • 12 December 201378. Emily E
    Upon the switch to Budeprion from Wellbutrin, I had terrible nightmares, side effects and my depression was MARKEDLY worse. My insurance won't cover Wellbutrin so I have to take expensive alternatives. $45 a month for Aplenzin! Phone Number 302 2416128
  • 25 November 201377. Erika H
    I'm being forced to take a generic that doesn't work as well as the Brand name because of insurance issues. I should be able to choose, since the two are clearly different.
  • 30 October 201376. Shanon B
    I support this petition
  • 16 October 201375. Jeanne C
    I support this petition
  • 29 August 201374. Gina H
    I support this petition

browse all the signatures


Dwight MckinneyBy:
Culture and SocietyIn:
Petition target:
Secretary Mike Leavitt, Department of Health and Human Services


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